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Abbott Initiates TREAT TR Study to Evaluate Real-World Outcomes of TriClip™ for Tricuspid Regurgitation
ABBOTT PARK, Ill. Prospective post-market study will enroll approximately 1,000 patients across the United States, Canada and Europe TriClip provides a minimally invasive treatment option for eligible patients with symptomatic tricuspid regurgitation who face increased surgical risk Abbott (NYSE: ABT) today announced the initiation of the TREAT TR study, a prospective post-market study evaluating the safety, performance […]
ABBOTT PARK, Ill.
Prospective post-market study will enroll approximately 1,000 patients across the United States, Canada and Europe
TriClip provides a minimally invasive treatment option for eligible patients with symptomatic tricuspid regurgitation who face increased surgical risk
Abbott (NYSE: ABT) today announced the initiation of the TREAT TR study, a prospective post-market study evaluating the safety, performance and clinical outcomes of the company’s TriClip™ transcatheter edge-to-edge repair system in real-world clinical practice.
TriClip is specifically designed to treat tricuspid regurgitation, or TR, a condition commonly known as a leaky tricuspid heart valve. The TREAT TR study will expand the body of clinical evidence supporting the system and assess its performance across a diverse population of patients, healthcare centers and geographic regions.
The first patient in the study was enrolled at Hospital Clínic de Barcelona in Spain by Xavier Freixa, M.D., and his cardiac team.
Study to Enroll Approximately 1,000 Patients
The prospective, observational, single-arm, multicenter study is expected to enroll approximately 1,000 patients at as many as 100 clinical sites in the United States, Canada and Europe.
Participants will be evaluated at hospital discharge, 30 days, six months and one year following treatment. Annual follow-up assessments will then continue for an additional four years, providing five years of clinical information for each participating patient.
A selected group of patients will also participate in a sub-study examining whether treatment with TriClip may reverse cardiac remodeling—the structural changes that can occur when the heart is injured or subjected to prolonged pressure or volume overload.
“Prior to TriClip’s availability, many patients with tricuspid regurgitation had few treatment options because medical therapy didn’t relieve their symptoms or they were at an increased risk for conventional open-heart surgery,” said Anita Asgar, M.D., section head of interventional cardiology and medical director for the Bluhm Cardiovascular Institute Structural Heart Program at Northwestern Medicine in Chicago and co-principal investigator of the TREAT TR study.
“Through multiple clinical studies and in working directly with patients, we’ve seen that TriClip can have a profound impact on the lives of people with TR, and we’re excited to see additional evidence to support this minimally invasive device.”
Addressing Tricuspid Regurgitation
The tricuspid valve controls blood flow from the heart’s right atrium to its right ventricle. Tricuspid regurgitation occurs when the valve does not close properly, allowing blood to flow backward through the valve.
The condition can force the heart to work harder and may cause symptoms including fatigue, swelling and shortness of breath. When left untreated, severe TR may contribute to complications such as atrial fibrillation and heart failure.
TriClip is intended to provide an additional treatment option for eligible patients who remain symptomatic despite medical therapy and are considered to be at elevated risk for conventional open-heart surgery.
The system’s transcatheter edge-to-edge repair technology is delivered through a vein in the leg. It works by clipping together portions of the tricuspid valve leaflets, helping the valve close more effectively and reducing backward blood flow without requiring open-heart surgery.
Patients treated with TriClip spend an average of approximately one day in the hospital following the procedure before returning home.
Clinical Evidence Supports TriClip Treatment
TriClip has been evaluated through several clinical studies, including the TRILUMINATE Pivotal trial. Results from the trial demonstrated that the system reduced the severity of tricuspid regurgitation, improved patients’ quality of life and supported reductions in heart-failure-related hospitalizations.
Findings from the TRILUMINATE Pivotal trial supported approval of the TriClip system by the U.S. Food and Drug Administration.
Additional real-world evidence was presented in June 2026 at the New York Valves conference. The analysis included 3,035 patients recorded in the Society of Thoracic Surgeons and American College of Cardiology Transcatheter Valve Therapy Registry across 278 clinical sites in the United States.
The registry findings showed outcomes consistent with those observed in the TRILUMINATE Pivotal trial, including meaningful reductions in TR severity and improvements in patients’ quality of life.
“Clinical studies have continued to reinforce the benefits of repairing the tricuspid valve with TriClip and the significant improvements that it brings to people’s daily lives, including reducing the rate of hospitalizations due to heart failure,” said Lars Sondergaard, M.D., chief medical officer of Abbott’s structural heart business.
“We believe the TREAT TR study will further confirm TriClip’s safety profile and effectiveness in reducing tricuspid regurgitation across a diverse range of patients and locations.”
About the TREAT TR Study
TREAT TR is a prospective, observational, single-arm, multicenter post-market study designed to evaluate the safety and real-world performance of the TriClip system.
The study will build upon existing clinical evidence and assess patient outcomes across a broader range of clinical environments, populations and geographic locations.
About TriClip™
TriClip is a minimally invasive treatment option designed to repair the tricuspid valve through transcatheter edge-to-edge repair.
The system has been approved for use in more than 50 countries, including the United States, Canada and countries across Europe, since receiving its initial CE Mark approval in 2020. TriClip has been used to treat more than 15,000 people with tricuspid regurgitation.
For important U.S. safety information regarding TriClip, visit:
About Abbott
Abbott (NYSE: ABT) is a global healthcare company that develops technologies designed to help people live more fully throughout all stages of life.
The company’s portfolio includes products and services across diagnostics, medical devices, nutrition and branded generic medicines. Abbott employs approximately 122,000 people and serves customers in more than 160 countries.
For additional information, visit Abbott.com.
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Abbott
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Duane Brecklin Proposes Expiry Labels for Crypto Forecasts to Keep Outdated Analysis from Living On
Cape Town, South Africa, September 16, 2026The proposed Forecast Expiry Label would make observation periods, invalidation conditions and revision histories visible, helping readers recognise when an assessment remains relevant and when it needs another look.
The proposed Forecast Expiry Label would make observation periods, invalidation conditions and revision histories visible, helping readers recognise when an assessment remains relevant and when it needs another look.
Cape Town, South Africa, September 16, 2026
When a market analysis is written, it usually has a clear context: the price at the time, the available data and the developments the analyst expects to follow. But when that analysis becomes a screenshot, circulates through a group chat or resurfaces weeks later, much of that context can disappear. What remains may be a conclusion that still sounds certain.

To address this problem, independent crypto market analyst and market-education contributor Duane Brecklin is proposing the Forecast Expiry Label, a method for attaching an observation window, scope, invalidation conditions and review date to crypto market analysis. The premise is straightforward: readers should have a way to tell whether an assessment still applies to the market in front of them.
The proposal builds on the focus of his earlier South African cross-border crypto research, extending the discussion from the circumstances surrounding asset movements to the boundaries within which market assessments should be used.
Old Analysis Keeps Circulating After Its Assumptions Have Changed
Crypto market commentary can be read and shared at any time. An article addressing short-term price behaviour may be saved as a long-term outlook. A chart prepared for one trading pair may be detached from its original explanation and used to interpret another market.
For readers, understanding the chart is only part of the challenge. Less obvious questions often matter just as much: What period was the author discussing? Which conditions supported the assessment? Do those conditions still hold?
The Forecast Expiry Label would bring that information into view, rather than leaving it in a footnote or buried among unstated assumptions. Under the proposal, an analysis would identify the asset and trading pair, observation window, primary and alternative scenarios, data sources, invalidation conditions, next review date, and relevant holdings or conflicts of interest.
These details need not become a lengthy technical statement. They should answer practical questions: What does this analysis cover? When should it be checked again? What would make it unsuitable for continued use?
Expiry Calls for Review, Not an Escape from Being Wrong
The proposal distinguishes between an observation period ending and the conditions supporting an assessment breaking down.
The first calls for a fresh examination of the evidence. An old view should not automatically remain valid simply because no update has appeared. The second requires a timely response, even if the scheduled review date has not yet arrived. When new information conflicts with the original assumptions, a date on the calendar is no reason to keep the conclusion unchanged.
An expiry label should not provide an excuse for a missed forecast, either. If an analysis makes a claim about market behaviour within a specified period, its review should accurately record the outcome. The purpose of an expiry date is to make accountability clearer, not to let an unfulfilled prediction quietly disappear.
That distinction matters to readers. They need more than an updated answer. They also need to understand why yesterday’s assessment changed, which evidence prompted the change and which questions remain unresolved.
Maintained, Revised or Withdrawn—Each Outcome Needs a Record
Under the proposal, a reviewed analysis could be marked as maintained, revised or withdrawn.
Maintaining an assessment would require an explanation of why its supporting evidence still holds. Revising it would mean retaining the earlier version and identifying the assumptions that changed. Withdrawing it would signal that the original assessment is no longer suitable as a reference and should no longer be relied upon.
Each status would carry a timestamp and an explanation. Revisions and withdrawals, in particular, should not happen solely through edits that overwrite the original text. Otherwise, later readers may struggle to understand what changed, while people who saved an earlier screenshot may continue using a conclusion the author has already abandoned.
Withdrawing an analysis is not always comfortable. But the value of research also lies in how it responds to evidence that contradicts expectations. Making that process visible gives readers a fuller understanding of analytical work than showing only the conclusions that eventually proved correct.
The Method’s Limitations Belong in the Same Record
The Forecast Expiry Label is currently a proposal for discussion. It is not an established industry standard, nor does it imply improved forecasting accuracy.
It cannot remove market volatility, replace scrutiny of data quality or automatically make subjective analysis objective. Methods including Elliott Wave analysis can produce different interpretations depending on the observation scale, starting point and analytical choices. Adding a label would simply make those conditions easier to examine.
For Duane Brecklin, the proposal addresses a specific and often overlooked part of market education: ensuring that analysis retains its essential context and limitations after it has been shared.
An assessment can take a clear position and later turn out to be wrong. Readers should at least be able to see what supported it—and when that support changed.
About Duane Brecklin
Duane Brecklin is an independent crypto market analyst and market-education contributor focused on crypto asset market structure, analytical methods and risk communication. His work examines the conditions under which market assessments apply and how those assessments should be reviewed.
This material is provided for general information and market-education purposes only and does not constitute investment advice. Crypto assets are highly volatile and may result in substantial losses.
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Duane Brecklin
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Genius.fun Launches on BNB Chain to Bring Hostile Takeovers On-chain
CaymanNew launchpad enables crypto communities to launch tokens, accumulate public-company shares and coordinate around corporate ownership
New launchpad enables crypto communities to launch tokens, accumulate public-company shares and coordinate around corporate ownership
Cayman
Genius Foundation today announced the launch of genius.fun, a new BNB Chain launchpad designed to help online communities coordinate capital and pursue ownership in publicly traded companies.

Genius.fun connects internet-native tokens with tokenized public-company shares, enabling decentralized communities to organize around a company, accumulate its equity and pursue shareholder initiatives, board representation or even hostile takeovers. By applying crypto-native markets and permissionless coordination to public-company ownership, it offers an alternative to structures traditionally dominated by investment banks, private-equity firms and activist funds.
Armaan Kalsi, CEO of Shuttle Labs, commented, “We’re excited by the Genius Foundation’s efforts to create a new primitive for crypto-native corporate power. We’re excited to see what happens when crypto native communities launch capital formation vehicles with 2 clicks and, for example, potentially do things like vie for board seats. A new capital formation vehicle with power to affect the real world is inherently exciting.”
From Memes to Real Ownership
Meme tokens have traditionally represented attention, identity and speculation. Genius.fun aims to turn that attention into coordinated economic power by allowing communities to launch tokens associated with public companies and pair them with tokenized shares.
Market activity can support further share accumulation, while eligible tokenized positions may be redeemed for the underlying equity. This creates a path beyond price exposure, allowing communities to pursue shareholder initiatives, activist campaigns, board representation or an acquisition strategy.
Built for Permissionless Coordination
Creators can pair tokens with BNB, USDT, USDC, Ondo, bStocks, xStocks or 4Stocks, with additional markets expected through gPerps. They can earn up to 1.25% of trading fees, while 0.25% supports buybacks and supply locking.
Token progress can be tracked from launch to graduation directly on its trading page. Tokens graduate at 15 $BNB through PancakeSwap, genius.fun’s graduation DEX partner.
Crypto-Anarchy Meets the Public Markets
Genius.fun is built on the belief that capital formation should not belong exclusively to investment banks, private-equity firms and activist funds. A meme can capture global attention within hours, while a token can turn that attention into a liquid market and a decentralized treasury that accumulates real assets.
The platform applies crypto’s culture of disruption, openness and voluntary coordination to public-company ownership. Its vision is that crypto’s next era will be defined not simply by bringing traditional assets on-chain, but by what global communities do with them once they get there.
The First On-chain Hostile Takeover
Genius.fun is working toward a future in which an online community can identify a public company, launch a market around it, accumulate a significant equity position and use that ownership to demand a voice.
At sufficient scale, that could mean pursuing a board seat, organizing an activist campaign or even attempting a hostile takeover. These strategies have historically been dominated by institutional investors and Wall Street firms. Genius.fun is exploring what happens when internet-native communities have the tools to pursue them as well.
A token launch can be the starting point. From there, communities can grow their market, build a treasury and coordinate around a company they want to influence.
Create your token. Choose your pair. Build your treasury. Take your seat.
Genius.fun is live at https://genius.fun.
About Genius Foundation
Genius Foundation builds crypto-native infrastructure for permissionless markets, collective ownership and decentralized economic coordination.
Its mission is to advance crypto’s original promise: replacing gatekeepers with open systems, converting online communities into economic forces and giving individuals the ability to organize capital on their own terms.
Genius.fun is the Foundation’s BNB Chain-based launchpad connecting token creation, tokenized public equities and community-led ownership.
Disclaimer: Participation in digital-asset and tokenized-securities markets involves significant risk. The availability, redemption and legal treatment of tokenized shares may depend on the applicable provider, jurisdiction and regulatory framework. References to corporate governance, board representation and takeover activity describe the platform’s intended use cases and long-term vision; they do not guarantee that any community will acquire a particular ownership interest or governance right. Nothing in this announcement constitutes an offer to buy or sell securities or financial, legal or investment advice.
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Jeffrey Chow
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Redefining Leadership Impact for Today’s Workforce
Tampa, FloridaAs organizations across the country continue to navigate rapid change, evolving employee expectations, and increasing pressure to strengthen workplace culture, Strategic Human Resources & Innovations (SHRI) announces a renewed focus on redefining leadership impact for today’s workforce. Led by Dr. Brittany Castonguay veteran, WOSB/SBA‑certified business owner, leadership expert, and author of Monomyth: A Leader’s Journey to Authenticity & Accountability SHRI is elevating the conversation around what modern leadership truly requires.
As organizations across the country continue to navigate rapid change, evolving employee expectations, and increasing pressure to strengthen workplace culture, Strategic Human Resources & Innovations (SHRI) announces a renewed focus on redefining leadership impact for today’s workforce. Led by Dr. Brittany Castonguay veteran, WOSB/SBA‑certified business owner, leadership expert, and author of Monomyth: A Leader’s Journey to Authenticity & Accountability SHRI is elevating the conversation around what modern leadership truly requires.
Tampa, Florida
Redefining Leadership Impact for Today’s Workforce
As organizations across the country continue to navigate rapid change, evolving employee expectations, and increasing pressure to strengthen workplace culture, Strategic Human Resources & Innovations (SHRI) announces a renewed focus on redefining leadership impact for today’s workforce. Led by Dr. Brittany Castonguay veteran, WOSB/SBA‑certified business owner, leadership expert, and author of Monomyth: A Leader’s Journey to Authenticity & Accountability SHRI is elevating the conversation around what modern leadership truly requires.

In an era where communication breakdowns, culture challenges, and workforce disengagement are becoming more common, Dr. Castonguay’s work stands out for its human‑centered, evidence‑based approach. Her leadership philosophy emphasizes clarity, accountability, and authenticity themes deeply explored in Monomyth, which continues to resonate with leaders seeking practical, meaningful transformation.
“Today’s workforce is asking for something different,” Dr. Castonguay shares. “They want leaders who communicate clearly, who understand people, and who build cultures where employees feel valued. Leadership isn’t just about strategy anymore it’s about humanity.”
SHRI’s expanded focus aligns with rising national interest in leadership development, organizational health, and culture transformation. As companies adapt to hybrid work models, generational shifts, and new performance expectations, Dr. Castonguay’s insights are increasingly sought after by executives and event organizers looking for impactful speakers who can address the realities of modern leadership.
Her speaking engagements blend research, real‑world experience, and practical frameworks that help leaders rethink how they show up in their organizations. With her veteran background and WOSB/SBA certifications, she brings a unique perspective grounded in discipline, service, and mission‑driven leadership qualities that resonate strongly with both corporate and nonprofit audiences.
Dr. Castonguay’s message is clear: leadership must evolve. And SHRI is committed to helping organizations make that shift with confidence, clarity, and compassion.
Organizations, event planners, and HR leaders interested in booking Dr. Castonguay for speaking engagements, leadership events, or organizational training sessions are encouraged to reach out directly to SHRI to schedule a meeting. The team is happy to answer any questions or provide additional information.
SHRI – Making Leadership Human
Tampa, FL | (813) 556‑3283 | [email protected]
WOSB | SBA Certified | Veteran Owned
Your HR Firm Next Door
Hours:
Monday – Friday: 9 AM – 5 PM
Closed Saturday & Sunday
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