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Sam Kamra Launches RealEstateBuyer.ca to Help Ontario and Alberta Homeowners Sell Their Homes for Cash

TORONTO, OntarioFounded by Sam Kamra, RealEstateBuyer.ca provides homeowners with a faster, more predictable alternative to the traditional home-selling process through direct cash purchases, flexible closing dates and as-is property acquisitions.

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Founded by Sam Kamra, RealEstateBuyer.ca provides homeowners with a faster, more predictable alternative to the traditional home-selling process through direct cash purchases, flexible closing dates and as-is property acquisitions.

Sam Kamra, Founder of RealEstateBuyer.ca and a licensed Real Estate Sales Representative, today announced the official launch of RealEstateBuyer.ca, a direct cash home-buying platform created to provide homeowners across Southern Ontario and major cities throughout Alberta with a faster, more convenient alternative to the traditional home-selling process.

 

ChatGPT Image Aug 6 2026 11 38 18 AM Sam Kamra Launches RealEstateBuyer.ca to Help Ontario and Alberta Homeowners Sell Their Homes for Cash

 

The announcement comes at a time when Canada’s housing market continues to adjust to elevated borrowing costs, increased housing inventory, stricter mortgage qualification requirements and longer selling timelines. Across many communities in Ontario and Alberta, homeowners are finding that selling a property through traditional methods has become more complex, more expensive and significantly less predictable than in previous years.

For many sellers, listing a property on the open market means preparing the home for sale through repairs, painting, cleaning, staging, landscaping and professional photography before the first showing even takes place. Once listed, homeowners may spend weeks or months accommodating showings, reviewing offers and negotiating with prospective purchasers, only to discover that a transaction remains conditional upon financing, inspections or the sale of another property. In some cases, transactions collapse entirely when financing cannot be obtained or contractual conditions are not satisfied.

As interest rates have risen and lending standards have tightened, obtaining mortgage approval has become increasingly difficult for many buyers. Even qualified purchasers may face delays during the underwriting process, leaving sellers with uncertainty regarding whether their transaction will ultimately close. For homeowners facing time-sensitive circumstances, these delays can create significant financial and emotional stress.

Recognizing these challenges, Sam Kamra established RealEstateBuyer.ca to provide property owners with a straightforward alternative centred on certainty, convenience and speed. Rather than marketing a property through the traditional Multiple Listing Service (MLS®) and waiting for third-party buyers to secure financing, RealEstateBuyer.ca purchases homes directly from sellers using private capital, allowing homeowners to receive a firm, no-obligation cash offer without many of the delays associated with conventional real estate transactions.

“Our objective was to create a solution for homeowners who value certainty,” said Sam Kamra, Founder of RealEstateBuyer.ca. “Every homeowner’s situation is different. Some people are relocating, managing an estate, dealing with financial hardship or simply want to avoid months of uncertainty while waiting for a buyer to obtain mortgage approval. We wanted to create a professional, transparent and straightforward process that gives homeowners another option.”

Unlike a conventional sale, homeowners who sell directly to RealEstateBuyer.ca do not need to prepare their property for multiple showings, host open houses or invest substantial sums into cosmetic improvements before listing. Depending on the location and services provided, sellers may also avoid paying real estate commissions, which can be as high as 6% plus applicable taxes, along with many of the expenses associated with preparing a home for the market.

Another significant advantage is certainty of financing. Because RealEstateBuyer.ca purchases properties directly, sellers do not have to wait while a purchaser seeks mortgage approval or worry about a transaction collapsing because financing conditions cannot be satisfied. This provides homeowners with greater confidence that an agreed-upon closing date can proceed as planned.

RealEstateBuyer.ca purchases residential properties on an “as is, where is” basis. Homeowners are not required to complete repairs, renovations or cosmetic improvements before selling. Depending on the property and the information available, RealEstateBuyer.ca may also purchase homes without requiring an interior inspection. In many instances, offers can be prepared using publicly available information, photographs, supporting documentation or a brief exterior review, helping to streamline the transaction for homeowners seeking a fast and convenient sale.

Subject to the terms of the purchase agreement, RealEstateBuyer.ca assumes ownership of the property upon closing, allowing sellers to move forward with confidence without the uncertainty of addressing future property-related concerns after the sale. This approach provides peace of mind for many homeowners who simply want a clean, efficient and predictable transaction.

The launch of RealEstateBuyer.ca reflects a broader shift in today’s housing market, where many homeowners are placing increasing value on speed, privacy and certainty of closing rather than navigating the lengthy and often unpredictable process associated with traditional home sales. As market conditions continue to evolve, direct cash home-buying solutions are becoming an increasingly attractive option for homeowners seeking greater flexibility and control over how they sell their property.

RealEstateBuyer.ca was developed to assist homeowners facing a wide variety of circumstances where selling through traditional methods may be impractical, time-consuming or financially challenging. While every transaction is unique, the company specializes in purchasing properties that often require a more flexible and experienced approach than a conventional buyer may be willing or able to provide.

The platform regularly considers properties in situations including:

  • Estate and probate sales
  • Inherited properties
  •  Tenant-occupied homes, including properties with non-paying or difficult tenants
  •  Properties involved in Landlord and Tenant Board (LTB) proceedings
  •  Distressed properties
  •  Vacant homes
  •  Fire- and flood-damaged properties
  •  Hoarder homes
  •  Homes affected by mould or pest infestations
  •  Properties requiring significant repairs or deferred maintenance
  •  Partially renovated or unfinished construction projects
  •  Properties subject to municipal stop work orders or outstanding compliance matters
  •  Power of Sale properties
  •  Homes where sellers require a confidential or expedited transaction
  •  Homeowners facing separation, divorce, relocation, financial hardship or other life transitions

According to Sam Kamra, many of these properties present challenges that can make obtaining conventional mortgage financing difficult for retail buyers. Even when a willing purchaser is found, financing approvals may be delayed or declined because of the property’s condition or the lender’s underwriting requirements.

“Many homeowners assume their only option is to list on the open market and hope the right buyer comes along,” said Kamra. “In reality, certain properties can be difficult to finance because of their condition or the circumstances surrounding the sale. Our objective is to simplify the process by purchasing directly, allowing homeowners to avoid many of those obstacles and move forward with certainty.”

Unlike a traditional home sale, RealEstateBuyer.ca is designed to provide flexibility throughout the transaction. Homeowners may choose a closing date that works best for their individual circumstances, with closing periods commonly ranging from approximately one week to three months, depending on the property and the seller’s needs.

The company also recognizes that not every homeowner has the financial resources to prepare a property before listing it for sale. Renovations, painting, cleaning, staging, landscaping, storage costs and ongoing mortgage, tax and utility payments can quickly become expensive while a property remains on the market.

By purchasing homes in their existing condition, RealEstateBuyer.ca allows sellers to avoid many of those upfront expenses. There is no requirement to complete cosmetic improvements, replace flooring, modernize kitchens or bathrooms, repair roofing, finish renovations or prepare the property for repeated buyer showings before requesting an offer.

Depending on the circumstances, RealEstateBuyer.ca may also purchase properties without requiring an interior inspection. In many cases, publicly available records, photographs, supporting documentation and a brief exterior review may provide sufficient information to evaluate the property and prepare a cash offer, allowing the transaction to proceed more efficiently.

This streamlined approach is particularly valuable for homeowners who live outside the area, have inherited vacant properties, own investment properties requiring substantial repairs or simply wish to avoid the inconvenience of preparing a home for the traditional market.

RealEstateBuyer.ca purchases properties on an “as is, where is” basis. Subject to the terms of the purchase agreement, ownership transfers to RealEstateBuyer.ca upon closing, allowing sellers to complete their sale without the ongoing uncertainty of addressing future property-related concerns after the transaction has been finalized.

The company’s acquisition model is intended to remove many of the common uncertainties associated with traditional residential real estate transactions, including financing conditions, lengthy negotiation periods, repeated buyer visits and unexpected delays prior to closing.

RealEstateBuyer.ca currently purchases residential properties throughout the Greater Toronto Area, including Toronto, Peel Region, York Region, Durham Region and Halton Region, while also serving Hamilton, Burlington, Oakville, Milton, Guelph, Cambridge, Kitchener-Waterloo, London, Niagara Region and many surrounding communities across Southern Ontario.

The company has also expanded its direct home-buying operations into Alberta, including Calgary, Edmonton, Red Deer, Airdrie, Fort McMurray and surrounding municipalities, providing homeowners in those markets with the same opportunity to receive direct cash offers and flexible closing options.

Homeowners interested in selling can begin the process by submitting their property’s location and basic information through RealEstateBuyer.ca. The company reviews current market conditions, comparable sales, property characteristics and other available information before preparing a confidential, no-obligation cash offer.

For many sellers, the process eliminates months of uncertainty while providing a simple alternative to the traditional listing process. Rather than waiting for multiple showings, financing approvals and conditional offers, homeowners can work directly with RealEstateBuyer.ca to determine whether a cash purchase is the right solution for their circumstances.

The company believes that every homeowner deserves options. While selling on the open market remains appropriate for many properties, direct cash purchases can provide an effective alternative for those who prioritize certainty, speed, convenience and privacy over the traditional listing process.

As Canada’s housing market continues to evolve, Sam Kamra believes homeowners should have access to more than one path when it comes to selling their property. While the traditional MLS® process remains an excellent option for many sellers, it is not the right solution for every situation. Homeowners facing time-sensitive circumstances, complex properties or financing uncertainty often require greater flexibility and certainty than the conventional market can provide.

“Our goal isn’t to replace the traditional real estate market,” said Kamra. “It’s to provide homeowners with another option. Every property and every seller has different priorities. Some people want to maximize price through the open market, while others value speed, convenience, privacy and certainty. RealEstateBuyer.ca was built to provide a professional solution for homeowners who simply want a straightforward sale without many of the uncertainties that can accompany a traditional transaction.”

By combining licensed real estate experience with a direct purchasing model, RealEstateBuyer.ca has created a platform designed to simplify the selling process for homeowners across Ontario and Alberta. Whether a property requires significant repairs, is occupied by tenants, forms part of an estate, or presents financing challenges for conventional buyers, the company aims to provide a practical alternative through direct cash purchases and flexible closing options.

As market conditions continue to change, RealEstateBuyer.ca expects demand for direct home-buying services to increase as more homeowners seek dependable solutions that reduce uncertainty and allow them to move forward with confidence.

About Sam Kamra

Sam Kamra is a licensed Real Estate Sales Representative with RE/MAX Millennium Real Estate and the founder of RealEstateBuyer.ca. With more than 12 years of experience in residential real estate, Sam specializes in helping homeowners navigate both traditional real estate transactions and direct property sales. He has participated in transactions representing more than $1 billion in cumulative real estate value and is recognized for his expertise in residential sales, distressed properties, investment real estate, and complex real estate transactions throughout Southern Ontario. Homeowners can learn more about Sam and his services at SamKamra.ca, while his professional profile is also available on Realtor.ca.

About RealEstateBuyer.ca

RealEstateBuyer.ca is the direct home-buying division of Real Estate Bay. The company purchases residential properties directly from homeowners throughout Southern Ontario and major cities across Alberta using private capital. RealEstateBuyer.ca specializes in purchasing homes on an “as is, where is” basis, providing homeowners with direct cash offers, flexible closing dates and an alternative to the traditional home-selling process. Subject to the terms of each purchase agreement, ownership transfers to RealEstateBuyer.ca upon closing, allowing sellers to move forward with confidence following the completion of their sale.

About Real Estate Bay

Real Estate Bay is a Canadian real estate platform focused on residential real estate marketing, MLS® property listings and direct residential property acquisitions. In addition to operating RealEstateBuyer.ca, the company markets residential properties throughout Ontario and Alberta while continuing to expand its presence within Canada’s evolving housing market.

Media Contact

Sam Kamra
Founder, RealEstateBuyer.ca
220 Duncan Mill Road
Toronto, Ontario M3B 2V1
Telephone: 416-877-1307
Email: [email protected]
Website: RealEstateBuyer.ca

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Nonprofit Organization, Citizens Academy US, Makes Official Public Release of Guide to Complete Understanding of the Preamble to the U.S. Constitution

Washington, DCCitizens Academy U.S., a nonprofit dedicated to helping Americans understand the U.S. Constitution’s Preamble, has officially released The Guide to Complete Understanding of the Preamble to the United States Constitution in celebration of Constitution Day, September 17. The organization is hosting a free online event, “The Day ‘We the People’ Appeared,” on September 13, 2026, […]

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Citizens Academy U.S., a nonprofit dedicated to helping Americans understand the U.S. Constitution’s Preamble, has officially released The Guide to Complete Understanding of the Preamble to the United States Constitution in celebration of Constitution Day, September 17. The organization is hosting a free online event, “The Day ‘We the People’ Appeared,” on September 13, 2026, exploring the Preamble and its six purposes.

The Preamble Guide Simplifies Understanding of the Six Purposes of the U.S. Constitution

In celebration of Constitution Day, September 17th, the Citizens Academy U.S., a nonprofit organization with the goal to help hundreds of millions of Americans understand the Preamble to the U.S. Constitution, just made their official public release of The Guide to Complete Understanding of the Preamble to the United States Constitution.

 

max 1 Nonprofit Organization, Citizens Academy US, Makes Official Public Release of Guide to Complete Understanding of the Preamble to the U.S. Constitution
Citizens Academy US is making the official public release of their Preamble Guide, a free download on their website with hardcover and softcover editions available

As noted on their website, the Preamble lays out all six purposes of the U.S. Constitution, and they are working to restore clarity and shared understanding of the Preamble and thus these six purposes. They do not explain or interpret what it means, they provide an enjoyable and easy way to completely understand it, so people can make up their own mind as to what it means.

Constitution Day is celebrated annually across the U.S. every September 17th as it is the day when 39 delegates signed the United States Constitution at Independence Hall in Philadelphia in 1787. In addition to the official release of their Guide, Citizens Academy US is hosting a free online event on Sunday, September 13, 2026, at 11am PT/2pm ET, entitled, The Day “We the People” Appeared. The event is expected to run for 1.5 hours and is open to free public registration at this link.

Academy officials have observed that many Americans who have attempted to read the Constitution have difficulty in understanding it. They attribute this to the fact that languages change over time, and many words do not mean what they meant when the Constitution was drafted. “Definitions from the late 1700s vary drastically from today’s definitions,” said Academy spokesperson Steven Ferry, “and it is vitally important that the Constitution is read with reference to the original definitions in use at the time it was written.”

To help people overcome this challenge, Citizens Academy US provides definitions in their Guide based on those from Noah Webster’s 1828 American Dictionary of the English Language. This early dictionary reveals what the words meant to the Founders and the people at the time the Constitution was written.

As an example, the definition of “welfare” in the Guide, based on Webster’s 1828 dictionary is: “the enjoyment of peace and prosperity, and other benefits of society, such as protection of rights, public safety, justice, and liberty.” Today’s Oxford Learner’s Dictionary includes an additional definition which people often refer to: “practical or financial help that is provided, often by the government, for people or animals that need it.”

Academy officials have also observed that when the Preamble is read with the original definitions in mind, understanding the six purposes of the Constitution becomes simple and the results are profound. The principle that forms the basis of the Guide is a quote by best-selling author L. Ron Hubbard, who wrote, “Complete understanding depends upon freedom from misunderstood words.”

By visiting the Citizens Academy US website, you can view the Guide and download it for free or purchase the hardcover or softcover in their bookstore.

 

max 2 Nonprofit Organization, Citizens Academy US, Makes Official Public Release of Guide to Complete Understanding of the Preamble to the U.S. Constitution

In honor of Constitution Day, Citizens Academy US is hosting a free online event, titled “The Day ‘We the People’ Appeared” on September 13, 2026, at 11am PT/2pm ET

 

The Citizens Academy US is a fully IRS recognized 501 (c)(3) charitable organization with the mission to bring about a greater understanding in America. The goal of the Citizens Academy US is to have 100’s of millions of Americans understand the first sentence of the United States Constitution, which is called the Preamble. The Preamble contains the six purposes of the Constitution and understanding the Preamble enables Americans to grasp what the Constitution is meant to achieve.

For more information about Citizens Academy US, please visit: www.CitizensAcademy.us

Media Contact Details
Steven Ferry
Citizens Academy US
Email: Send Email
Phone: 727-492-4082
Website: citizensacademy.us

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Ángela Rodríguez Expands REFLEJO™ Method and Inclusive Beauty Education Initiatives

NEW YORK, USAAuthor, Beauty Educator, and founder of Divina Makeup advances international education, accessibility, and community-focused programs centered on makeup, autonomy, and women’s empowerment.

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Author, Beauty Educator, and founder of Divina Makeup advances international education, accessibility, and community-focused programs centered on makeup, autonomy, and women’s empowerment.

Colombian-born author, Beauty Educator, and entrepreneur Ángela Rodríguez is expanding her work around the REFLEJO™ Method, an educational self-makeup methodology designed to help women better understand their individual features, needs, and personal approach to beauty.

 

1000494238 Ángela Rodríguez Expands REFLEJO™ Method and Inclusive Beauty Education Initiatives

 

Ángela, founder of Divina Makeup and author of Maquíllate en 6 Pasos (Make Yourself Up in 6 Steps), is developing the next stage of her educational platform through an updated edition of her book, digital learning resources, accessibility initiatives, international outreach, and community programs focused on women’s confidence, autonomy, and inclusion.

At the center of the initiative is the REFLEJO™ Method, which is based on the principle that every woman is unique and should learn to understand her own face rather than simply reproduce makeup techniques created for someone else.

For Ángela, makeup education extends beyond teaching the application of foundation, concealer, or eyeshadow. Her approach focuses on providing women with practical knowledge that can help them make informed decisions about their appearance while developing greater confidence in their own skills.

“True transformation begins when a woman learns to see herself differently,” Ángela said.

Expanding the REFLEJO™ Method

Ángela is currently developing a new edition of Maquíllate en 6 Pasos that will incorporate the REFLEJO™ Method and expand the educational resources available to readers.

The new edition is planned to include QR codes connecting readers with complementary audiovisual learning materials. The project is also being developed with accessibility resources intended to make makeup education more inclusive for people with hearing disabilities, including sign language interpretation and subtitled content.

The initiative reflects Ángela’s broader objective of making beauty education more accessible to women with different backgrounds, ages, cultures, and life experiences.

She also intends to expand the REFLEJO™ Method internationally as an educational framework that can be used across workshops, community programs, and other learning environments.

From New York Fashion Platforms to Education

Since arriving in New York in 2020, Ángela has worked across several areas of the beauty industry while establishing herself as an educator, author, professional makeup artist, and entrepreneur.

 

1000494239 Ángela Rodríguez Expands REFLEJO™ Method and Inclusive Beauty Education Initiatives

 

Her professional experience has included participation in major New York fashion platforms, including New York Fashion Week, where she has held leadership roles within makeup teams.

Alongside her work as a makeup artist, Ángela has focused on creating professional development opportunities for emerging artists. She has supported initiatives that allow aspiring makeup professionals to gain experience at fashion shows, develop portfolios, strengthen practical skills, and gain exposure to professional working environments.

Her makeup artistry has also appeared in publications and magazine covers connected with New York and France.

As an educator and entrepreneur, Ángela has participated in events throughout the Latino community in the United States, using those opportunities to discuss makeup education, entrepreneurship, confidence, and professional development.

Bogotá International Book Fair Milestone

In 2026, Ángela participated in the Bogotá International Book Fair (FILBo), where she presented her work as an author and discussed her approach to connecting makeup education with women’s empowerment.

The appearance represented another step in Ángela’s effort to expand her work beyond traditional beauty services and develop a broader educational platform.

Her current work builds on that experience by integrating her published material with the REFLEJO™ Method, digital education, accessibility, and community engagement.

Bringing Beauty Education to Communities

Ángela is also strengthening partnerships and developing social initiatives aimed at providing free workshops focused on self-makeup, self-esteem, and empowerment.

The planned initiatives are intended to reach women in Afro-descendant, rural, and Indigenous communities in Colombia, as well as other populations that may have limited access to beauty education and related professional-development opportunities.

Through these programs, Ángela aims to apply the experience she has developed in the beauty industry to educational and community-based settings.

She has also begun collaborating with organizations and foundations that support women while developing a broader social-impact platform centered on education, leadership, inclusion, and dignity.

Connecting Beauty Education With Women’s Rights

Ángela recently participated in an event held within the context of the United Nations focused on education for peace and human rights.

She describes the experience as an important development in her work and one that strengthened her interest in participating in initiatives involving women’s rights, education, dignity, and access to opportunity.

Her long-term vision is to connect beauty education with wider social-impact initiatives and establish strategic partnerships capable of bringing those programs to additional communities.

For Ángela, women’s empowerment encompasses more than personal appearance. Her work increasingly addresses education, autonomy, inclusion, professional opportunity, dignity, and women’s ability to make informed decisions about their own lives.

An Immigrant Entrepreneur Building From New York

Ángela’s professional development also reflects her experience as a Colombian immigrant establishing a career in the United States.

Since moving to New York in 2020, she has worked to build her professional identity across makeup artistry, education, publishing, and entrepreneurship while developing Divina Makeup and the REFLEJO™ Method.

Her focus has gradually shifted from applying makeup for clients toward teaching women how to understand their individual features, develop practical skills, and approach their personal image with greater independence.

Through fashion, education, publishing, community initiatives, and international outreach, Ángela is continuing to develop a platform that brings together beauty education and social purpose.

About Ángela Rodríguez

Ángela Rodríguez is a Colombian-born author, professional makeup artist, Beauty Educator, entrepreneur, and creator of the REFLEJO™ Method. She is the founder of Divina Makeup and author of Maquíllate en 6 Pasos. Based in New York, her work focuses on self-makeup education, professional development, inclusion, accessibility, women’s empowerment, and community-focused initiatives.

Instagram: @divina.make.up

Media Contact

Ángela Rodríguez
Author | Beauty Educator | Creator of the REFLEJO™ Method
Founder, Divina Makeup
New York, United States
Instagram: @divina.make.up

Photo Credit: Photos accompanying this release were taken by New York-based photographer Dong Yang.

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BTI, Cornell Develop AI Tool to Map Hidden Universe of Small Molecules

Ithaca, NYResearchers at the Boyce Thompson Institute and Cornell University have developed AIMe (AI Molecule Explorer), a neuro-symbolic AI tool that predicts, organizes, and searches mass spectra for more than 100 million known small organic molecules—creating a searchable map of chemical space roughly a thousand times larger than existing experimental libraries. Applying AIMe to gut microbiome data, the team identified a previously unknown, ring-shaped polyamine compound also found in human fecal samples, and used the tool to annotate millions of unidentified spectra in a major public mass spectrometry database.

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Researchers at the Boyce Thompson Institute and Cornell University have developed AIMe (AI Molecule Explorer), a neuro-symbolic AI tool that predicts, organizes, and searches mass spectra for more than 100 million known small organic molecules—creating a searchable map of chemical space roughly a thousand times larger than existing experimental libraries. Applying AIMe to gut microbiome data, the team identified a previously unknown, ring-shaped polyamine compound also found in human fecal samples, and used the tool to annotate millions of unidentified spectra in a major public mass spectrometry database.

Researchers at the Boyce Thompson Institute (BTI) and Cornell University unveiled AIMe (AI Molecule Explorer), a neuro-symbolic artificial intelligence tool that predicts and maps the mass spectra of more than 100 million known small organic molecules. The tool tackles a long-standing bottleneck in biomedical science—more than 80% of small molecules detected in a typical biological sample cannot be matched to a known structure—a gap that has stalled discoveries linking the gut microbiome, immunity, and metabolism.

 

Screenshot of AIMe results BTI, Cornell Develop AI Tool to Map Hidden Universe of Small Molecules

 

The work is a collaboration between Frank Schroeder, Professor at BTI and in Cornell’s Department of Chemistry and Chemical Biology, and Carla Gomes, Professor of Computing and Information Science and director of Cornell’s AI for Science Institute.

A different approach to an old problem

Mass spectrometry is the workhorse for small molecule identification used in a wide range of applications from toxicology to food analysis. When a compound is analyzed, the instrument fragments it and records the masses of the resulting pieces. That pattern of fragments, the tandem mass spectrum (or MS2 spectrum), functions as a molecular fingerprint. To identify an unknown compound, researchers compare its spectrum against a reference library of spectra from known compounds or develop hypotheses as to what the structure of a compound may be based on manual analysis of the fragmentation pattern.

The problem is that experimental reference libraries remain sparse, while expert, one-by-one interpretation is labor-intensive and slow. Collectively, available libraries cover fewer than 1% of known compounds, and resolving the structure of a single unknown can take days to months of iterative analysis and experimental validation. As a result, spectra without close library matches usually remain unannotated.

AIMe takes a different approach. Rather than waiting for experimental spectra to accumulate in libraries, it predicts spectra computationally—then organizes those predictions into a searchable resource called MS2KOSMOS. AIMe generated more than 800 million predicted spectra covering essentially all known small organic molecules in PubChem, the largest publicly available chemical database. That represents roughly a thousandfold expansion of searchable chemical space relative to existing experimental libraries.

“At the core of AIMe is DeepMS2Reasoner, a model that simulates how molecules fragment inside a mass spectrometer,” explained Gomes. “It builds fragmentation pathways step by step, using symbolic chemical rules to enumerate physically plausible fragmentation steps and a neural network to assign likelihoods to each step. The result is a predicted spectrum and an annotated map of how a molecule came apart—a feature that makes AIMe’s outputs interpretable in chemical terms, not just computationally useful.”

From mouse gut to human biology

To demonstrate what AIMe can do in practice, the researchers applied it to a comparative metabolomics dataset from mice. The experiment compared germ-free mice, animals raised without any gut microbiota, against mice with a normal complement of gut bacteria. Several thousand chemical features differed between the two groups, and most of the abundant ones could not be identified using standard methods.

The team used AIMe to query MS2KOSMOS with spectra from the 111 most abundant unidentified microbiota-dependent compounds. For roughly a third, AIMe retrieved close predicted spectral matches and related structural candidates, providing chemically interpretable leads for follow-up. For the rest, AIMe mapped the unknown spectra to molecular neighborhoods—sets of structurally related compounds whose shared fragmentation patterns could inform hypotheses about what the unknowns might be.

“Two compounds in particular became a case study in what AI-guided structure elucidation can accomplish,” said Schroeder. “Both produced spectra that suggested they were polyamine derivatives, a well-studied class of molecules, but the fragment patterns didn’t match anything previously described. Using AIMe’s output as a guide, our team assembled candidate structures combinatorially, predicted spectra for each candidate, and used the comparison to narrow the field.”

For the first compound, the best candidate was a linear putrescine derivative, which was then easily verified by synthesizing an authentic standard. For the second, the predicted spectra of potential candidates consistently failed to explain two prominent peaks—until the team expanded the search to include cyclized variants.

Synthesis confirmed what the predictions suggested. The second compound turned out to be a structurally unusual macrocyclic polyamine—a ring-shaped variant unlike any previously reported from mouse or human biology. Searches of a large public mass spectrometry database subsequently found the same compound in samples of human origin, detected in 57 of 99 human fecal samples examined.

Polyamines occupy an important position in biology. They sit at the intersection of diet, the gut microbiome, and immune function—and these findings suggest that the catalog of microbiota-dependent polyamines is far less complete than scientists assumed.

Annotation at scale

The researchers also tested AIMe at repository scale, applying it to more than 7 million spectral clusters from the Global Natural Products Social Molecular Networking database, one of the largest publicly available repositories of mass spectrometry data. Prior annotation efforts had annotated roughly 416,000 of those clusters. AIMe returned putative annotations for approximately 2.69 million, using the same similarity threshold applied in that earlier effort.

AIMe is accessible at https://www.cs.cornell.edu/gomes/udiscoverit/kosmos/ and the source code will be made publicly available upon publication of the study. The preprint is available on bioRxiv (DOI: 10.64898/2026.08.05.743095).

About the Boyce Thompson Institute (BTI)

As an independent nonprofit research institute affiliated with Cornell University, our scientists are committed to advancing solutions for global food security, agricultural sustainability, and human health. Through groundbreaking research, transformative education, and rapid translation of discoveries into real-world applications, BTI bridges fundamental plant and molecular science with practical impact. Discovery inspired by plants since 1924. Learn more at BTIscience.org.

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