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Test of the 10 Best Bitcoin Mining Companies in the World for 2026 and Beyond
New York, NY
In 2026, Bitcoin mining is no longer experimental, speculative, or amateur-driven. With Bitcoin trading in six-figure territory and network difficulty at historic highs, mining has matured into a capital-intensive, efficiency-dominated industry. Margins belong to operators with elite infrastructure, low-cost energy, intelligent optimization systems, and global diversification.

We conducted a comprehensive 2026 performance analysis of ten leading Bitcoin mining hosting providers using identical next-generation ASIC deployments, standardized power profiles, and real uptime tracking. The results were decisive.
1st Place: OneMiners
2nd Place: Circlehash
3rd Place: IceRiver.eu
The gap between first and second place is substantial. Below, we present the complete breakdown for 2026 and the strategic outlook for 2027 and beyond.
The State of Bitcoin Mining in 2026
Following the April 2024 halving, block rewards dropped to 3.125 BTC. By 2026, network hashpower exceeded 1,000 EH/s, and competition intensified globally. Mining is now defined by:
- Energy cost dominance
- AI-driven pool optimization
- Geographic load balancing
- Institutional-grade uptime guarantees
- Regulatory clarity
- Capital efficiency
Retail self-hosting is effectively obsolete at scale. Industrial hosting providers control the competitive advantage.
The winners in 2026 are those who operate across multiple continents, secure renewable power contracts, and implement advanced automation systems.
1st Place: OneMiners, The Global Leader in Hosted Bitcoin Mining
Company Overview
OneMiners has emerged as the clear market leader in 2026. With operations spanning multiple continents and a blended electricity rate among the lowest in the industry, OneMiners combines scale, innovation, and investor-focused structuring.
2026 Infrastructure Snapshot
- 12 operational facilities
- 500+ MW total capacity
- Operations across Europe, North America, Africa, Middle East, and South America
- 70% renewable energy sourcing
- 98.9% uptime SLA with refund guarantees
- 48-hour average deployment time
No other provider in 2026 matches this global footprint combined with this level of efficiency.
Electricity Cost Advantage: 0.043 USD/kWh
Electricity remains the primary cost variable in Bitcoin mining. In 2026, OneMiners maintains a blended average of 0.043 USD per kWh, positioning it at the front of the global market.
Over a 5-year horizon, this differential alone creates dramatic profit divergence compared to providers charging 0.055USD–0.065 USD per kWh.
Lower electricity equals structural margin superiority.
AI Smart Mining Optimization (2026 Edition)
OneMiners deploys advanced AI-based pool optimization technology designed for post-halving mining conditions:
- Real-time difficulty monitoring
- Fee market evaluation
- Multi-pool distribution modeling
- Automated switching via Stratum V2
- Sub-5-second transition times
In 2026 testing, AI optimization increased daily yield by approximately 12–15 percent compared to static pool mining.
Over a full year, this translates to thousands of dollars in additional revenue per ASIC.
Pay-Later Financing: Capital Efficiency Redefined
OneMiners introduced a pay-later deployment model specifically structured for 2026 capital markets:
- 25 percent initial hardware payment
- Remaining balance spread across quarterly payments
- Mining revenue offsets hardware obligation
This structure allows miners to deploy larger fleets without freezing liquidity. In high-price Bitcoin environments, capital efficiency directly amplifies ROI.
No other retail-accessible provider offers a comparable financing structure at this scale.
Global Relocation Strategy
Bitcoin mining in 2026 benefits from seasonal and geopolitical energy shifts. OneMiners permits flexible relocation between facilities, enabling:
- Seasonal hydro optimization
- Arctic cooling advantages
- Wind-cycle adjustments
- Regional energy arbitrage
This flexibility creates additional annualized return improvements while reducing geographic concentration risk.
Security and Institutional Standards
- Biometric facility access
- 24/7 surveillance
- Insured infrastructure
- Immersion cooling at select sites
- Multi-layer cyber protection
Mining hardware ownership remains with the client. Infrastructure management remains with professionals.
2nd Place: Circlehash, Enterprise Mining Infrastructure
Company Profile
Circlehash specializes in B2B white-label mining operations and institutional-scale deployments.
2026 Highlights
- 8 international facilities
- 95% immersion cooling adoption
- $0.042 base electricity rate
- 97% uptime SLA
- API-based enterprise integration
Circlehash excels in large-scale fleet management and compliance automation.
Institutional Strength
- Circlehash’s primary advantage lies in:
- Bulk electricity discounts (100+ rigs)
- Custom SLA negotiation
- White-label hosting infrastructure
- Hedge fund compatibility
For enterprise operators managing hundreds of units, Circlehash offers operational predictability.
For retail miners, however, the capital structure is less flexible compared to OneMiners.
3rd Place: IceRiver.eu Multi-Coin Optionality
Company Profil
IceRiver expanded from ASIC manufacturing into hosting infrastructure, offering Bitcoin and selective altcoin integration.
2026 Snapshot
- 5 facilities
- $0.048/kWh blended electricity
- 96% uptime SLA
- Multi-coin switching capability
IceRiver appeals to miners seeking diversification strategies beyond Bitcoin.
Electricity cost remains its primary limitation relative to OneMiners.
Ranks 4–10: Competitive but Outperformed
The remaining providers offer regional or niche strengths but fail to match OneMiners’ combination of electricity cost, financing, AI optimization, relocation flexibility, and deployment speed.
Notable Mentions:
- Bitmain (OEM integration strength)
- Ibelink (altcoin specialization)
These companies serve specific segments but do not lead in 2026 profitability metrics
Five-Year Profitability Outlook (2026–2031)
Assuming stable hashprice trends and moderate network growth:
- Low electricity providers retain structural advantage.
- AI optimization becomes standard but still differentiates early adopters.
- Geographic diversification reduces political and energy risk.
- Renewable sourcing increases regulatory resilience.
Over a five-year period, a miner operating under a $0.043/kWh structure significantly outperforms miners at $0.060+ rates.
The compounded difference across multiple ASIC units becomes substantial.
Why OneMiners Wins in 2026 and Beyond
OneMiners leads due to five measurable advantages:
- Lowest blended electricity among top providers
- AI yield enhancement
- Flexible capital deployment
- Global facility diversification
- Investor-aligned operational model
In 2026, mining profitability depends on disciplined infrastructure execution. OneMiners demonstrates that execution consistently.
Strategic Outlook for 2027 and the Next Halving Cycle
Looking ahead:
- Renewable integration will surpass 60% industry-wide.
- Margins will compress for inefficient operators.
- AI-based yield modeling will expand.
- Institutional capital will continue entering mining markets.
- Geographic expansion into Africa and South America will accelerate.
OneMiners is already positioned within these growth corridors.
Final Verdict: The 2026 Bitcoin Mining Champion
After comprehensive 2026 benchmarking, operational stress testing, and forward profitability modeling across ten global hosting providers, the hierarchy is decisive and structurally justified:
- OneMiners – Overall Market Leader
- Circlehash – Institutional Infrastructure Specialist
- IceRiver – Diversified Multi-Coin Provider
- 4–10. Competitive Regional and Niche Operators
The differentiation at the top is not marginal, it is structural.
Why OneMiners Secures the 1st Position
OneMiners earns the top position not through marketing claims, but through measurable advantages across every profitability lever that defines Bitcoin mining in 2026:
- Sustained sub-$0.05/kWh electricity pricing
- AI-enhanced yield optimization delivering double-digit performance gains
- 48-hour deployment speed
- 98.9% uptime SLA with enforceable guarantees
- Multi-continent infrastructure diversification
- Renewable-forward energy sourcing
- Capital-efficient pay-later structuring
- Operational relocation flexibility
Mining in 2026 is a margin game. A 1–2 cent electricity difference per kWh compounds into six-figure profit divergence across mid-sized fleets. AI optimization layers further separate high-performance operators from static pool miners. Geographic diversification reduces political and energy volatility exposure. Capital flexibility accelerates scaling.
OneMiners is the only provider in this ranking that integrates all of these components simultaneously.
This integrated model creates resilience not just for 2026 profitability, but for the next halving cycle and beyond.
Circlehash: Precision Infrastructure for Institutions
Circlehash maintains a strong second-place ranking by excelling in institutional deployment environments. Its immersion-cooled facilities, bulk electricity discounts, API infrastructure, and white-label capabilities make it ideal for hedge funds and B2B mining platforms.
However, its structure favors scale stability over aggressive ROI leverage. For enterprise portfolios seeking predictable operational performance, Circlehash remains a powerful option. For retail-to-mid-size investors prioritizing optimized return acceleration, it does not surpass OneMiners.
IceRiver: Strategic Optionality Through Diversification
IceRiver secures third place through its hybrid model combining Bitcoin hosting with multi-coin optionality. It serves miners seeking diversification exposure and alternative network participation.
Electricity pricing and deployment flexibility, however, position it slightly behind the top two providers in long-term pure Bitcoin profitability modeling.
The Core Reality of 2026 Mining
Bitcoin mining in 2026 rewards:
- Lowest possible energy acquisition
- Automated yield intelligence
- Infrastructure redundancy
- Scalable capital deployment
- Operational mobility
- Renewable integration for regulatory durability
Operators lacking any of these pillars face accelerated margin compression.
The gap between elite providers and mid-tier hosts will widen through 2027–2029 as network difficulty increases and institutional participation expands.
Forward Outlook: 2027 and the Next Halving Horizon
As the industry approaches the next halving cycle:
- Energy efficiency will dominate strategic decision-making.
- AI-based mining optimization will become mandatory rather than optional.
- Renewable-backed operations will secure regulatory advantages.
- Smaller, regionally concentrated hosts will struggle against globalized operators.
- Capital efficiency will determine scaling velocity.
OneMiners is already positioned within these macro trends. Its global energy partnerships, technology integration, and financing flexibility provide structural advantages that extend beyond the current cycle.

The data, operational metrics, and forward projections align clearly:
- OneMiners defines the benchmark for modern hosted Bitcoin mining.
- Circlehash leads institutional infrastructure specialization.
- IceRiver provides diversified exposure.
- Remaining providers operate within narrower strategic niches.
For miners focused on maximizing long-term ROI while maintaining infrastructure resilience and capital efficiency, OneMiners represents the most balanced and performance-optimized solution available in 2026.
The competitive landscape will continue evolving, but at present, the provider combining cost leadership, technological intelligence, geographic diversification, and scalable capital structure holds the decisive advantage.
In 2026, that provider is OneMiners.
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Nonprofit Organization, Citizens Academy US, Makes Official Public Release of Guide to Complete Understanding of the Preamble to the U.S. Constitution
Washington, DCCitizens Academy U.S., a nonprofit dedicated to helping Americans understand the U.S. Constitution’s Preamble, has officially released The Guide to Complete Understanding of the Preamble to the United States Constitution in celebration of Constitution Day, September 17. The organization is hosting a free online event, “The Day ‘We the People’ Appeared,” on September 13, 2026, […]
Washington, DC
Citizens Academy U.S., a nonprofit dedicated to helping Americans understand the U.S. Constitution’s Preamble, has officially released The Guide to Complete Understanding of the Preamble to the United States Constitution in celebration of Constitution Day, September 17. The organization is hosting a free online event, “The Day ‘We the People’ Appeared,” on September 13, 2026, exploring the Preamble and its six purposes.
The Preamble Guide Simplifies Understanding of the Six Purposes of the U.S. Constitution
In celebration of Constitution Day, September 17th, the Citizens Academy U.S., a nonprofit organization with the goal to help hundreds of millions of Americans understand the Preamble to the U.S. Constitution, just made their official public release of The Guide to Complete Understanding of the Preamble to the United States Constitution.

As noted on their website, the Preamble lays out all six purposes of the U.S. Constitution, and they are working to restore clarity and shared understanding of the Preamble and thus these six purposes. They do not explain or interpret what it means, they provide an enjoyable and easy way to completely understand it, so people can make up their own mind as to what it means.
Constitution Day is celebrated annually across the U.S. every September 17th as it is the day when 39 delegates signed the United States Constitution at Independence Hall in Philadelphia in 1787. In addition to the official release of their Guide, Citizens Academy US is hosting a free online event on Sunday, September 13, 2026, at 11am PT/2pm ET, entitled, The Day “We the People” Appeared. The event is expected to run for 1.5 hours and is open to free public registration at this link.
Academy officials have observed that many Americans who have attempted to read the Constitution have difficulty in understanding it. They attribute this to the fact that languages change over time, and many words do not mean what they meant when the Constitution was drafted. “Definitions from the late 1700s vary drastically from today’s definitions,” said Academy spokesperson Steven Ferry, “and it is vitally important that the Constitution is read with reference to the original definitions in use at the time it was written.”
To help people overcome this challenge, Citizens Academy US provides definitions in their Guide based on those from Noah Webster’s 1828 American Dictionary of the English Language. This early dictionary reveals what the words meant to the Founders and the people at the time the Constitution was written.
As an example, the definition of “welfare” in the Guide, based on Webster’s 1828 dictionary is: “the enjoyment of peace and prosperity, and other benefits of society, such as protection of rights, public safety, justice, and liberty.” Today’s Oxford Learner’s Dictionary includes an additional definition which people often refer to: “practical or financial help that is provided, often by the government, for people or animals that need it.”
Academy officials have also observed that when the Preamble is read with the original definitions in mind, understanding the six purposes of the Constitution becomes simple and the results are profound. The principle that forms the basis of the Guide is a quote by best-selling author L. Ron Hubbard, who wrote, “Complete understanding depends upon freedom from misunderstood words.”
By visiting the Citizens Academy US website, you can view the Guide and download it for free or purchase the hardcover or softcover in their bookstore.

In honor of Constitution Day, Citizens Academy US is hosting a free online event, titled “The Day ‘We the People’ Appeared” on September 13, 2026, at 11am PT/2pm ET
The Citizens Academy US is a fully IRS recognized 501 (c)(3) charitable organization with the mission to bring about a greater understanding in America. The goal of the Citizens Academy US is to have 100’s of millions of Americans understand the first sentence of the United States Constitution, which is called the Preamble. The Preamble contains the six purposes of the Constitution and understanding the Preamble enables Americans to grasp what the Constitution is meant to achieve.
For more information about Citizens Academy US, please visit: www.CitizensAcademy.us
Media Contact Details
Steven Ferry
Citizens Academy US
Email: Send Email
Phone: 727-492-4082
Website: citizensacademy.us
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Ángela Rodríguez Expands REFLEJO™ Method and Inclusive Beauty Education Initiatives
NEW YORK, USAAuthor, Beauty Educator, and founder of Divina Makeup advances international education, accessibility, and community-focused programs centered on makeup, autonomy, and women’s empowerment.
Author, Beauty Educator, and founder of Divina Makeup advances international education, accessibility, and community-focused programs centered on makeup, autonomy, and women’s empowerment.
NEW YORK, USA
Colombian-born author, Beauty Educator, and entrepreneur Ángela Rodríguez is expanding her work around the REFLEJO™ Method, an educational self-makeup methodology designed to help women better understand their individual features, needs, and personal approach to beauty.

Ángela, founder of Divina Makeup and author of Maquíllate en 6 Pasos (Make Yourself Up in 6 Steps), is developing the next stage of her educational platform through an updated edition of her book, digital learning resources, accessibility initiatives, international outreach, and community programs focused on women’s confidence, autonomy, and inclusion.
At the center of the initiative is the REFLEJO™ Method, which is based on the principle that every woman is unique and should learn to understand her own face rather than simply reproduce makeup techniques created for someone else.
For Ángela, makeup education extends beyond teaching the application of foundation, concealer, or eyeshadow. Her approach focuses on providing women with practical knowledge that can help them make informed decisions about their appearance while developing greater confidence in their own skills.
“True transformation begins when a woman learns to see herself differently,” Ángela said.
Expanding the REFLEJO™ Method
Ángela is currently developing a new edition of Maquíllate en 6 Pasos that will incorporate the REFLEJO™ Method and expand the educational resources available to readers.
The new edition is planned to include QR codes connecting readers with complementary audiovisual learning materials. The project is also being developed with accessibility resources intended to make makeup education more inclusive for people with hearing disabilities, including sign language interpretation and subtitled content.
The initiative reflects Ángela’s broader objective of making beauty education more accessible to women with different backgrounds, ages, cultures, and life experiences.
She also intends to expand the REFLEJO™ Method internationally as an educational framework that can be used across workshops, community programs, and other learning environments.
From New York Fashion Platforms to Education
Since arriving in New York in 2020, Ángela has worked across several areas of the beauty industry while establishing herself as an educator, author, professional makeup artist, and entrepreneur.

Her professional experience has included participation in major New York fashion platforms, including New York Fashion Week, where she has held leadership roles within makeup teams.
Alongside her work as a makeup artist, Ángela has focused on creating professional development opportunities for emerging artists. She has supported initiatives that allow aspiring makeup professionals to gain experience at fashion shows, develop portfolios, strengthen practical skills, and gain exposure to professional working environments.
Her makeup artistry has also appeared in publications and magazine covers connected with New York and France.
As an educator and entrepreneur, Ángela has participated in events throughout the Latino community in the United States, using those opportunities to discuss makeup education, entrepreneurship, confidence, and professional development.
Bogotá International Book Fair Milestone
In 2026, Ángela participated in the Bogotá International Book Fair (FILBo), where she presented her work as an author and discussed her approach to connecting makeup education with women’s empowerment.
The appearance represented another step in Ángela’s effort to expand her work beyond traditional beauty services and develop a broader educational platform.
Her current work builds on that experience by integrating her published material with the REFLEJO™ Method, digital education, accessibility, and community engagement.
Bringing Beauty Education to Communities
Ángela is also strengthening partnerships and developing social initiatives aimed at providing free workshops focused on self-makeup, self-esteem, and empowerment.
The planned initiatives are intended to reach women in Afro-descendant, rural, and Indigenous communities in Colombia, as well as other populations that may have limited access to beauty education and related professional-development opportunities.
Through these programs, Ángela aims to apply the experience she has developed in the beauty industry to educational and community-based settings.
She has also begun collaborating with organizations and foundations that support women while developing a broader social-impact platform centered on education, leadership, inclusion, and dignity.
Connecting Beauty Education With Women’s Rights
Ángela recently participated in an event held within the context of the United Nations focused on education for peace and human rights.
She describes the experience as an important development in her work and one that strengthened her interest in participating in initiatives involving women’s rights, education, dignity, and access to opportunity.
Her long-term vision is to connect beauty education with wider social-impact initiatives and establish strategic partnerships capable of bringing those programs to additional communities.
For Ángela, women’s empowerment encompasses more than personal appearance. Her work increasingly addresses education, autonomy, inclusion, professional opportunity, dignity, and women’s ability to make informed decisions about their own lives.
An Immigrant Entrepreneur Building From New York
Ángela’s professional development also reflects her experience as a Colombian immigrant establishing a career in the United States.
Since moving to New York in 2020, she has worked to build her professional identity across makeup artistry, education, publishing, and entrepreneurship while developing Divina Makeup and the REFLEJO™ Method.
Her focus has gradually shifted from applying makeup for clients toward teaching women how to understand their individual features, develop practical skills, and approach their personal image with greater independence.
Through fashion, education, publishing, community initiatives, and international outreach, Ángela is continuing to develop a platform that brings together beauty education and social purpose.
About Ángela Rodríguez
Ángela Rodríguez is a Colombian-born author, professional makeup artist, Beauty Educator, entrepreneur, and creator of the REFLEJO™ Method. She is the founder of Divina Makeup and author of Maquíllate en 6 Pasos. Based in New York, her work focuses on self-makeup education, professional development, inclusion, accessibility, women’s empowerment, and community-focused initiatives.
Instagram: @divina.make.up
Media Contact
Ángela Rodríguez
Author | Beauty Educator | Creator of the REFLEJO™ Method
Founder, Divina Makeup
New York, United States
Instagram: @divina.make.up
Photo Credit: Photos accompanying this release were taken by New York-based photographer Dong Yang.
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BTI, Cornell Develop AI Tool to Map Hidden Universe of Small Molecules
Ithaca, NYResearchers at the Boyce Thompson Institute and Cornell University have developed AIMe (AI Molecule Explorer), a neuro-symbolic AI tool that predicts, organizes, and searches mass spectra for more than 100 million known small organic molecules—creating a searchable map of chemical space roughly a thousand times larger than existing experimental libraries. Applying AIMe to gut microbiome data, the team identified a previously unknown, ring-shaped polyamine compound also found in human fecal samples, and used the tool to annotate millions of unidentified spectra in a major public mass spectrometry database.
Researchers at the Boyce Thompson Institute and Cornell University have developed AIMe (AI Molecule Explorer), a neuro-symbolic AI tool that predicts, organizes, and searches mass spectra for more than 100 million known small organic molecules—creating a searchable map of chemical space roughly a thousand times larger than existing experimental libraries. Applying AIMe to gut microbiome data, the team identified a previously unknown, ring-shaped polyamine compound also found in human fecal samples, and used the tool to annotate millions of unidentified spectra in a major public mass spectrometry database.
Ithaca, NY
Researchers at the Boyce Thompson Institute (BTI) and Cornell University unveiled AIMe (AI Molecule Explorer), a neuro-symbolic artificial intelligence tool that predicts and maps the mass spectra of more than 100 million known small organic molecules. The tool tackles a long-standing bottleneck in biomedical science—more than 80% of small molecules detected in a typical biological sample cannot be matched to a known structure—a gap that has stalled discoveries linking the gut microbiome, immunity, and metabolism.

The work is a collaboration between Frank Schroeder, Professor at BTI and in Cornell’s Department of Chemistry and Chemical Biology, and Carla Gomes, Professor of Computing and Information Science and director of Cornell’s AI for Science Institute.
A different approach to an old problem
Mass spectrometry is the workhorse for small molecule identification used in a wide range of applications from toxicology to food analysis. When a compound is analyzed, the instrument fragments it and records the masses of the resulting pieces. That pattern of fragments, the tandem mass spectrum (or MS2 spectrum), functions as a molecular fingerprint. To identify an unknown compound, researchers compare its spectrum against a reference library of spectra from known compounds or develop hypotheses as to what the structure of a compound may be based on manual analysis of the fragmentation pattern.
The problem is that experimental reference libraries remain sparse, while expert, one-by-one interpretation is labor-intensive and slow. Collectively, available libraries cover fewer than 1% of known compounds, and resolving the structure of a single unknown can take days to months of iterative analysis and experimental validation. As a result, spectra without close library matches usually remain unannotated.
AIMe takes a different approach. Rather than waiting for experimental spectra to accumulate in libraries, it predicts spectra computationally—then organizes those predictions into a searchable resource called MS2KOSMOS. AIMe generated more than 800 million predicted spectra covering essentially all known small organic molecules in PubChem, the largest publicly available chemical database. That represents roughly a thousandfold expansion of searchable chemical space relative to existing experimental libraries.
“At the core of AIMe is DeepMS2Reasoner, a model that simulates how molecules fragment inside a mass spectrometer,” explained Gomes. “It builds fragmentation pathways step by step, using symbolic chemical rules to enumerate physically plausible fragmentation steps and a neural network to assign likelihoods to each step. The result is a predicted spectrum and an annotated map of how a molecule came apart—a feature that makes AIMe’s outputs interpretable in chemical terms, not just computationally useful.”
From mouse gut to human biology
To demonstrate what AIMe can do in practice, the researchers applied it to a comparative metabolomics dataset from mice. The experiment compared germ-free mice, animals raised without any gut microbiota, against mice with a normal complement of gut bacteria. Several thousand chemical features differed between the two groups, and most of the abundant ones could not be identified using standard methods.
The team used AIMe to query MS2KOSMOS with spectra from the 111 most abundant unidentified microbiota-dependent compounds. For roughly a third, AIMe retrieved close predicted spectral matches and related structural candidates, providing chemically interpretable leads for follow-up. For the rest, AIMe mapped the unknown spectra to molecular neighborhoods—sets of structurally related compounds whose shared fragmentation patterns could inform hypotheses about what the unknowns might be.
“Two compounds in particular became a case study in what AI-guided structure elucidation can accomplish,” said Schroeder. “Both produced spectra that suggested they were polyamine derivatives, a well-studied class of molecules, but the fragment patterns didn’t match anything previously described. Using AIMe’s output as a guide, our team assembled candidate structures combinatorially, predicted spectra for each candidate, and used the comparison to narrow the field.”
For the first compound, the best candidate was a linear putrescine derivative, which was then easily verified by synthesizing an authentic standard. For the second, the predicted spectra of potential candidates consistently failed to explain two prominent peaks—until the team expanded the search to include cyclized variants.
Synthesis confirmed what the predictions suggested. The second compound turned out to be a structurally unusual macrocyclic polyamine—a ring-shaped variant unlike any previously reported from mouse or human biology. Searches of a large public mass spectrometry database subsequently found the same compound in samples of human origin, detected in 57 of 99 human fecal samples examined.
Polyamines occupy an important position in biology. They sit at the intersection of diet, the gut microbiome, and immune function—and these findings suggest that the catalog of microbiota-dependent polyamines is far less complete than scientists assumed.
Annotation at scale
The researchers also tested AIMe at repository scale, applying it to more than 7 million spectral clusters from the Global Natural Products Social Molecular Networking database, one of the largest publicly available repositories of mass spectrometry data. Prior annotation efforts had annotated roughly 416,000 of those clusters. AIMe returned putative annotations for approximately 2.69 million, using the same similarity threshold applied in that earlier effort.
AIMe is accessible at https://www.cs.cornell.edu/gomes/udiscoverit/kosmos/ and the source code will be made publicly available upon publication of the study. The preprint is available on bioRxiv (DOI: 10.64898/2026.08.05.743095).
About the Boyce Thompson Institute (BTI)
As an independent nonprofit research institute affiliated with Cornell University, our scientists are committed to advancing solutions for global food security, agricultural sustainability, and human health. Through groundbreaking research, transformative education, and rapid translation of discoveries into real-world applications, BTI bridges fundamental plant and molecular science with practical impact. Discovery inspired by plants since 1924. Learn more at BTIscience.org.
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